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作者应用重组α-干扰素治疗慢性丙型肝炎,并观察了HCV RNA从血清中清除与基因型的相互关系。 126例日本患者(男91例,女35例)均有慢性肝炎的组织学证据。血清HCV RNA均阳性(PCR法),抗-HCV阳性率为98.6％。乙型肝炎标志:HBsAg均阴性,抗-HBs和抗-HBc阳性率分别为25.2％和39.2％。所有患者抗-HIV阴性。根据血清学、生化以及组织学检查排除了自身免疫性肝炎。患者年龄25～63岁(平均47岁)。ALT
The authors applied recombinant IFN-α to treat chronic hepatitis C and observed the relationship of HCV RNA clearance from serum with genotypes. 126 Japanese patients (91 males and 35 females) have histological evidence of chronic hepatitis. Serum HCV RNA were positive (PCR method), anti-HCV positive rate was 98.6%. Hepatitis B markers: HBsAg were negative, anti-HBs and anti-HBc positive rates were 25.2% and 39.2%. All patients were anti-HIV negative. Autoimmune hepatitis was ruled out on the basis of serology, biochemistry and histology. Patients aged 25 to 63 years (mean 47 years). ALT