BAFF是 TNF超家族的一个新成员 ,属 型跨膜蛋白 ,由 2 85个氨基酸组成 ,通过与其受体结合而广泛参与 B、T淋巴细胞增殖和功能的调节。 BAFF缺乏可导致免疫功能低下 ,过表达则与多种自身免疫性疾病的发生和发展密切相关。BAFF可能还与某些肿瘤的发生有关。以 BAFF及受体为作用靶点 ,可以设计治疗相关疾病的新策略 BAFF, a new member of the TNF superfamily, is a type of transmembrane protein consisting of 2 to 85 amino acids that is widely involved in the regulation of B and T lymphocyte proliferation and function through its binding to its receptor. BAFF deficiency can lead to immune dysfunction, overexpression and a variety of autoimmune diseases are closely related to the occurrence and development. BAFF may also be associated with the occurrence of certain tumors. With BAFF and its receptors as targets, new strategies for the treatment of related diseases can be designed