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目的探讨氯吡格雷联合瑞舒伐他汀治疗不稳定型心绞痛的临床疗效及对其氧化应激的影响。方法抽取2014年10月至2016年3月收治的74例不稳定型心绞痛患者,根据入院先后顺序分为研究组与对照组,每组37例。对照组采用低分子肝素、硝酸酯类及阿司匹林治疗,研究组在对照组用药基础上加用氯吡格雷与瑞舒伐他汀。采用SPSS 20.0软件对两组临床疗效、治疗前后血脂水平各指标及氧化应激相关指标水平变化情况和不良反应发生情况进行统计分析。结果研究组治疗总有效率为91.89%,对照组为72.97%,两组比较差异有统计学意义(P<0.05);用药前两组总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、脂质过氧化物、丙二醛及超氧化物歧化酶水平比较差异未见统计学意义(P>0.05),经治疗,研究组各项指标水平均明显优于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为10.80%,对照组为8.10%,两组比较差异未见统计学意义(P>0.05)。结论在常规用药基础上联合采用氯吡格雷和瑞舒伐他汀治疗不稳定型心绞痛患者效果显著,可有效改善其血脂水平,减轻氧化应激,提高临床疗效,且不会增加不良反应发生,具有一定安全性。
Objective To investigate the clinical effects of clopidogrel combined with rosuvastatin in the treatment of unstable angina pectoris and its effect on oxidative stress. Methods Totally 74 patients with unstable angina pectoris admitted from October 2014 to March 2016 were divided into study group and control group according to the order of admission, with 37 cases in each group. The control group was treated with low molecular weight heparin, nitrates and aspirin. The study group was given clopidogrel and rosuvastatin on the basis of the control group. SPSS 20.0 software was used to analyze the clinical curative effect, the changes of blood lipid level before and after treatment, the level of oxidative stress related indicators and the occurrence of adverse reactions. Results The total effective rate was 91.89% in the study group and 72.97% in the control group, with significant difference between the two groups (P <0.05). Before treatment, total cholesterol, triglyceride, low density lipoprotein cholesterol, Lipoprotein cholesterol, lipid peroxides, malondialdehyde and superoxide dismutase levels were no significant difference (P> 0.05), after treatment, the study group indicators were significantly better than the control group, the difference (P <0.05). The incidence of adverse reactions was 10.80% in the study group and 8.10% in the control group. There was no significant difference between the two groups (P> 0.05). Conclusions The combination of clopidogrel and rosuvastatin on patients with unstable angina pectoris on the basis of routine medication has a significant effect, which can effectively improve the level of blood lipid, reduce the oxidative stress and improve the clinical efficacy without increasing adverse reactions, A certain safety.