细胞因子信号转导抑制因子3(SOCS3)通过调节细胞因子信号传导通路对多种细胞及细胞因子具有调节作用,是炎症和细胞凋亡的关键调节物。妊娠时母-胎单位局部微环境存在大量细胞因子,细胞因子参与妊娠期胚胎植入、胎盘形成、胎儿生长和分娩等过程,细胞因子受多方面因素精密调控,使之处于稳定状态有助于正常妊娠。SOCS3作为细胞因子信号传导调节因子参与妊娠及分娩过程,研究表明SOCS3表达异常与流产、早产、妊娠期高血压疾病和妊娠期糖尿病等妊娠疾病的发生发展有关,深入研究SOCS3在妊娠疾病中的作用,可以为妊娠相关疾病的诊断和治疗等方面提供理论依据。 Cytokine signal transduction inhibitor 3 (SOCS3) regulates a variety of cells and cytokines by modulating cytokine signaling pathways and is a key regulator of inflammation and apoptosis. During pregnancy, there are a large number of cytokines in the local microenvironment of the maternal-fetal unit. Cytokines are involved in the process of embryo implantation during pregnancy, placenta formation, fetal growth and childbirth. The cytokines are closely regulated by many factors to make them stable Normal pregnancy. SOCS3 as a regulator of cytokine signaling in pregnancy and childbirth process studies have shown that abnormal expression of SOCS3 and abortion, premature birth, pregnancy-induced hypertension and gestational diabetes mellitus and other pregnancy-related diseases and development, in-depth study of the role of SOCS3 in pregnancy disease , Can provide theoretical basis for the diagnosis and treatment of pregnancy-related diseases.