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目的：探讨静止性脑梗死(SCl)和脑白质损害(WML)对帕金森病(PD)运动症状的影响。方法：选取无中风史、头颅CT检查末见异常，年龄和病程配比的PD患者，观察3年后头颅MRI显示的SCl及WML的发生率及其对PD的运动功能的影响。结果：伴随高血压、糖尿病的PD患者较无伴随疾病者SCI及WML的发生率明显增高(P＜0．05)，出现SCI及WML患者的运动功能评分较无SCI及WML患者明显增加(P＜0．01)。结论：预防脑缺血损害对延缓PD病情进展、控制症状具有重要的临床意义。
Objective: To investigate the effect of resting cerebral infarction (SCl) and white matter damage (WML) on motor symptoms of Parkinson’s disease (PD). Methods: The PD patients with no history of stroke, cephalic CT findings, age and duration of disease were selected and the incidence of SCI and WML after 3 years and the effect on PD motor function were observed. Results: The incidence of SCI and WML in patients with hypertension and diabetes mellitus was significantly higher than those without SCI and WML (P <0.05). The scores of motor function in patients with SCI and WML were significantly higher than those without SCI and WML (P <0.01). Conclusion: Prevention of cerebral ischemic injury has an important clinical significance in retarding the progression of PD and controlling the symptoms.