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目的:观察胰岛素强化治疗对初诊2型糖尿病患者胰岛β细胞功能的影响。方法:将初诊2型糖尿病患者按胰岛素强化治疗4周过程中血糖控制速度不同分为A(快速血糖控制组)、B(非快速血糖控制组)两组,比较治疗前后及两组间HOMA-β、AUCCP30、AUCCP120的差异。结果:随着血糖水平下降,两组治疗后HOMA-β值较治疗前显著提高,差异有统计学意义;两组AUCCP30、AUCCP120的开始改善时间无统计学差异。结论:胰岛素强化降糖治疗可改善胰岛β细胞功能,降糖4周可使患者胰岛素早时相分泌改善。
Objective: To observe the effect of intensive insulin therapy on pancreatic β-cell function in newly diagnosed type 2 diabetic patients. Methods: Patients with newly diagnosed type 2 diabetes were divided into A (fasting glucose control group) and B (non-fasting glucose control group) according to the speed of blood glucose control during 4 weeks of intensive insulin therapy. HOMA- β, AUCCP30, AUCCP120 differences. Results: With the decrease of blood glucose, HOMA-β in both groups increased significantly after treatment compared with before treatment, the difference was statistically significant. There was no significant difference between the two groups in the starting time of AUCCP30 and AUCCP120. Conclusion: Hypoglycemic insulin therapy can improve pancreatic β-cell function, hypoglycemic 4 weeks can make patients with early insulin secretion improved.