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目的:观察还原型谷胱甘肽联合辛伐他汀治疗非酒精性脂肪性肝炎的临床疗效。方法:86例非酒精性脂肪性肝炎患者随机分为两组,对照组给予饮食控制,同时口服辛伐他汀5 mg,po,qn;治疗组在对照组基础上加用还原型谷胱甘肽1.8g,ivd,qd,两组疗程均为4周。结果:治疗组总有效率88.64%,明显高于对照组总有效率(61.90%)(P<0.05)。各组治疗后ALT及血清胆固醇、血清甘油三酯明显降低(P<0.01)。与对照组比较,治疗组治疗后ALT明显降低(P<0.05),血清胆固醇及血清甘油三酯差异无统计学意义(P>0.05)。结论:还原型谷胱甘肽联合辛伐他汀治疗非酒精性脂肪性肝炎能有效降低血清ALT水平,疗效明显优于单用辛伐他汀。
Objective: To observe the clinical efficacy of reduced glutathione and simvastatin in the treatment of non-alcoholic steatohepatitis. Methods: Eighty-six patients with non-alcoholic steatohepatitis were randomly divided into two groups. The control group was given diet control and simvastatin 5 mg, po, qn orally. The treatment group was treated with reduced glutathione 1.8g, ivd, qd, two courses are 4 weeks. Results: The total effective rate of the treatment group was 88.64%, which was significantly higher than that of the control group (61.90%) (P <0.05). After treatment, ALT, serum cholesterol and serum triglyceride were significantly decreased (P <0.01). Compared with the control group, the treatment group after treatment ALT was significantly lower (P <0.05), serum cholesterol and serum triglyceride difference was not statistically significant (P> 0.05). Conclusion: Reduced glutathione combined with simvastatin treatment of non-alcoholic steatohepatitis can effectively reduce serum ALT levels, the effect was significantly better than simvastatin alone.