Discovery of ferrocene-carborane derivatives as novel chemical antimicrobial agents against multidr

来源 :中国科学：化学英文版 | 被引量 : 0次 | 上传用户：wecofe

【摘要】

：

抗菌剂抵抗现在成为了一个很严重的全球公共健康问题。新药发现和开发着急地被需要与成长威胁作斗争 multidrug 抵抗(MDR ) 细菌。这研究的目的是探索三 ferrocene 碳硼衍生

【作者】

：

LI ShuiHong WU ChangYu LV XiaY

【机构】

：

StateKeyLaboratoryofBioelectronics（Chien-ShiungWuLaboratory）,SoutheastUniversity,SehoolofChemistryan

【出处】

：

中国科学：化学英文版

【发表日期】

：

2012年11期

【关键词】

：

多药耐药二茂铁衍生物抗菌剂硼烷细菌化学公共卫生问题 multidrug-resistant bacteria ferrocene-carbora

【基金项目】

：

supported by the National Natural Science Foundation of China (21175020),,National Key Basic Research Program (2010CB732404),,Doctoral Fund of Ministry of Education of China (20090092110028),,National

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抗菌剂抵抗现在成为了一个很严重的全球公共健康问题。新药发现和开发着急地被需要与成长威胁作斗争 multidrug 抵抗(MDR ) 细菌。这研究的目的是探索三 ferrocene 碳硼衍生物的潜在的申请同样新的答应代理人面对增加抗菌素抵抗的问题。琼脂散开生物鉴定，测试的最小的禁止的集中(MIC ) 和时间杀死试金的结果说明他们的用途广泛的抗菌剂活动到两美国类型文化收集(ATCC ) 控制紧张和 MDR 临床孤立。相关抗菌剂性质都以一种剂量依赖者方式并且逐渐地与增加药集中从细菌抑制的效果转变成杀菌效果，是明

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Discovery of ferrocene-carborane derivatives as novel chemical antimicrobial agents against multidr

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