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目的探讨尿微量白蛋白(MA)与冠状动脉(冠脉)病变的关系。方法 169例冠心病患者分为非糖尿病组99例,糖尿病组70例,均行冠脉造影(CAG),检测尿白蛋白/肌酐、尿素氮、肌酐、空腹血糖、2h 血糖、血脂等。冠脉病变程度通过病变血管数和冠脉病变积分两个指标表示。结果 (1)在非糖尿病组中,MA 阳性组的冠脉病变积分(7.90±3.07比5.77±2.87,P<0.05)和冠脉病变血管数(1.84±0.17比1.38±0.93,P<0.05)明显高于 MA 阴性组。(2)在糖尿病组中,MA阳性组的冠脉病变积分(8.15±3.40比5.86±3.06,P<0.05)和冠脉病变血管数(2.03±0.91比1.51±0.76,P<0.05)明显高于 MA 阴性组。多元逐步回归分析示:男性、MA、LDL-C、射血分数是冠脉病变积分的独立预测因子。结论筛查 MA 有助于发现冠脉病变严重的患者及疾病预后差的患者。
Objective To investigate the relationship between urinary microalbumin (MA) and coronary artery disease (coronary artery). Methods 169 patients with coronary heart disease were divided into non-diabetic group (n = 99) and diabetic group (n = 70). Coronary angiography (CAG) was performed. Urinary albumin / creatinine, urea nitrogen, creatinine, fasting blood glucose, blood glucose, The degree of coronary artery lesion through the number of lesions and coronary artery disease score points two indicators. Results (1) In the non-diabetic group, the coronary lesion score (7.90 ± 3.07 vs 5.77 ± 2.87, P <0.05) and coronary artery lesion (1.84 ± 0.17 vs 1.38 ± 0.93, P <0.05) Significantly higher than the MA negative group. (2) In the diabetic group, the score of coronary artery in MA-positive group (8.15 ± 3.40 vs 5.86 ± 3.06, P <0.05) and coronary artery lesion (2.03 ± 0.91 vs 1.51 ± 0.76, P <0.05) In the MA negative group. Multivariate stepwise regression analysis showed that male, MA, LDL-C and ejection fraction were independent predictors of coronary artery disease. Conclusion The screening of MA helps to identify patients with severe coronary artery disease and poor prognosis.