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已知 D-1和 D-2是中枢神经系统中两类多巴胺受体,腺垂体 D-2受体中介 PRL 分泌的抑制过程。R_022-1319最近被推荐为一种新型抗精神病药物,它能与 D-2受体结合,具有与止呕灵相似的特性。SCH23390为一种选择性 D-1受体拮抗剂,具有抗精神病作用。本实验以 PRL 水平为指标,研究了几种抗精神病药物对 D-2受体拮抗强度,并对 R_022-1319和 SCH23390与经典抗精神病药物的作用强度进行了比较。选重250～300克雄性 Wistar 大鼠,置于
It is known that D-1 and D-2 are two classes of dopamine receptors in the central nervous system, and suppress the secretion of PRL by the pituitary D-2 receptor. R_022-1319 has recently been recommended as a novel antipsychotic that binds to the D-2 receptor with similar properties to anticonvulsants. SCH23390 is a selective D-1 receptor antagonist with anti-psychotic effects. In this study, PRL levels as an index to study several antipsychotics D-2 receptor antagonistic strength, and R_022-1319 and SCH23390 and classic antipsychotic potency were compared. Weight 250 to 300 grams of male Wistar rats, placed