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本文通过对肾脏的廓清试验和微穿刺来研究β-肾上腺素能阻滞剂心得安对缺血后急性肾功能衰竭(ARF)的效用。方法用戊巴比妥(60mg/kg体重)注入鼠腹腔内使麻醉,然后剖腹暴露左肾,将左肾动脉阻断60分钟后引起严重的ARF。在阻断肾动脉前先作微穿刺及清除率作为对照。在阻断前后,一组19只鼠用心得安1mg/kg/h持续静滴,另一组16只单用0.85%盐水,并测血压、心率、肾血流量、菊粉清除率、尿流量、尿钠浓度、近端小管内压力及停流压(stop flow pressure)。结果在肾动脉阻断前心得安组血压及心率明显下降;而肾血流量及小球滤过率在两组无区别。左肾动脉阻断60分钟后,左肾血流量在两组均显著减少,心得安组下降43%到2.91 ml/min,盐水组下降33%到2.93 ml/min。左肾的肾血流量、尿流量及尿钠浓度在两组无显著不同。然而,菊粉清除率有显著不
In this paper, the effect of beta-adrenergic blocker propranolol on acute renal failure (ARF) after ischemia was studied through clearance of kidneys and micro-puncture. Methods Rats were injected intraperitoneally with pentobarbitone (60 mg / kg body weight) to induce anesthesia. Then the left kidney was exposed by cesarean section and the left renal artery was blocked for 60 minutes to cause severe ARF. Before blocking the renal artery for micro-puncture and clearance rate as a control. Before and after the blockade, a group of 19 rats were treated with 1 mg / kg / h of propranolol and another group of 16 with 0.85% saline alone. Blood pressure, heart rate, renal blood flow, inulin clearance, urine flow , Urinary sodium concentration, proximal endotracheal pressure and stop flow pressure. Results The blood pressure and heart rate of propranolol decreased significantly before the renal artery occlusion, while the renal blood flow and glomerular filtration rate had no difference between the two groups. After left renal artery occlusion for 60 minutes, left renal blood flow decreased significantly in both groups, with a decrease of 43% to 2.91 ml / min in the propranolol group and 33% to 2.93 ml / min in the saline group. Left kidney renal blood flow, urinary flow and urinary sodium concentration in the two groups no significant difference. However, inulin clearance was significantly different