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根据乳腺大汗腺癌、小管癌、黏液癌、浸润导管癌、单纯癌和髓样癌组织 Fourier变换红外光谱酰胺 I带的去卷积和拟合分析 ,获得组织中蛋白质二级结构的数目及其组成。结果表明 :这些组织中蛋白质二级结构的数目及其组成存在着显著的差异 ,并与组织的类型、分化、坏死等密切相关。其中 ,髓样癌的差异性最大 ;高分化癌中螺旋结构的含量及非典型螺旋和 α-螺旋含量的比值均比低分化癌的相应值高 ;肿瘤边缘坏死的乳腺癌组织也表现出明显的差异。乳腺癌组织蛋白质二级结构的分析对乳腺癌组织的表征和评价具有重要的意义。
According to the deconvolution and fitting analysis of Fourier Transform Infrared Spectroscopy (FTIR) I bands in patients with apocynovial carcinoma of the breast, tubal carcinoma, mucoid carcinoma, infiltrating ductal carcinoma, simple carcinoma and medullary carcinoma, the number of protein secondary structures in the tissues and their composition. The results showed that there was a significant difference in the number and composition of protein secondary structure in these tissues, which was closely related to the type of tissue, differentiation and necrosis. Among them, medullary carcinoma had the most difference; the ratio of helical structure and atypical helix and a-helix in highly differentiated carcinoma was higher than that in poorly differentiated carcinoma; the tumor tissue with marginal necrosis also showed obvious The difference. Analysis of breast cancer protein secondary structure of breast cancer tissue characterization and evaluation of great significance.