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[目的]探讨阿霉素为主介入化疗对Q-T间期离散度的影响。[方法]回顾性、单盲法分析32例肿瘤患者行以阿霉素为主介入化疗后对Q-T离散度(Q-Td)和心率校正Q-T离散度(Q-Tcd)的影响。[结果]化疗前Q-Td、Q-Tcd分别为(53.59±15.76)ms、(60.3±16.06)ms,化疗后Q-Td、Q-Tcd分别为(60.5±18.34)ms(69.21±19.01)ms,经t检验,P值均小于0.05。[结论]Q-Td作为一种监测化疗药物心脏毒性的简便、有效指标具有重要的临床意义。
[Objective] To investigate the effect of doxorubicin-based interventional chemotherapy on Q-T interval dispersion. [Methods] Retrospective, single-blind method was used to analyze the effects of doxorubicin-based interventional chemotherapy on Q-T dispersion (Q-Td) and Q-T dispersion (Q-Tcd) in 32 patients with cancer. [Results] Before chemotherapy, Q-Td and Q-Tcd were (53.59±15.76) ms and (60.3±16.06) ms respectively. After chemotherapy, Q-Td and Q-Tcd were (60.5±18.34) ms (69.21±19.01). Ms, the t-test, P values were less than 0.05. [Conclusion] Q-Td has important clinical significance as a simple and effective index for monitoring cardiotoxicity of chemotherapy drugs.