南五加萜酸具有生胃酮样抗溃疡活性,剂量为50～100mg/kg时对大鼠消炎痛型、幽门结扎型和无水乙醇型溃疡模型均具有良好的保护作用。南五加萜酸可显著升高幽门结扎大鼠胃液中氨基己糖含量,对胃液分泌和胃蛋白酶活性无明显影响,提示其可增加胃粘膜的保护因素。生胃酮对大鼠尿Na~+及K~+的排泄均有明显的抑制作用,对钠负荷大鼠有增加尿K~+排泄的作用;但南五加萜酸对正常及钠负荷大鼠尿Na~+及K~+的排泄均无明显影响,提示其不会引起动物和人水钠潴留。 Antagonistic antitumor activity of nandaganic acid was observed in rats with indomethacin-induced, pyloric ligation and ethanol-induced ulcer models at a dosage of 50-100 mg / kg. NADP can significantly increase the content of hexosamines in gastric juice of pylorus ligation rats, but have no significant effect on gastric juice secretion and pepsin activity, suggesting that it may increase the protective factors of gastric mucosa. Endosulfanone significantly inhibited the excretion of urinary Na ~ + and K ~ + in rats and increased urinary excretion of K ~ + in sodium-loaded rats. However, NADPH played an important role in the normal and sodium overload Rat urinary Na ~ + and K ~ + excretion had no significant effect, suggesting that it will not cause water and sodium retention in animals and humans.