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目的 探讨膀胱癌中Ｅ钙粘素（Ｅｃｄ） 的表达及其临床意义。方法 采用免疫组织化学ＬＳＡＢ 法对６９ 例膀胱癌进行Ｅｃｄ 检测。结果 ６９ 例膀胱癌标本中３５ 例Ｅｃｄ 正常表达（５０ ．７ ％ ） ，Ｅｃｄ 的正常表达率在Ⅰ、Ⅱ、Ⅲ级肿瘤中分别为７２ ．２ ％ ，６５ ．２ ％ 和２５ ．０ ％ ，在Ｔｉｓ ～Ｔ１ 期和Ｔ２～Ｔ４ 期肿瘤中分别为７８ ．８ ％ 和２５ ．０ ％ 。Ｅｃｄ 的正常表达率随膀胱癌的病理分级和临床分期上升而下降，其正常表达者的肿瘤复发率和死亡率明显低于异常表达者。结论 Ｅ钙粘素的异常表达在膀胱肿瘤的恶性进展过程中起着重要作用，可以作为判断膀胱肿瘤恶性程度及预后的指标。
Objective To investigate the expression of E-cadherin (E-cad) in bladder cancer and its clinical significance. Methods Immunohistochemical LSAB method for 69 cases of bladder cancer E cd detection. Results 69 cases of bladder cancer specimens 35 cases of normal expression of E cd (50.7%), E cd normal expression rate in Ⅰ, Ⅱ, Ⅲ grade tumors were 72. 2%, 65. 2% and 25. 0% in the Tis ~ T1 and T2 ~ T4 tumors were 78. 8% and 25. 0%. The normal expression rate of E CD with the pathological grading and clinical stage of bladder cancer decreased, and its normal expression of tumor recurrence and mortality was significantly lower than those with abnormal expression. Conclusion The abnormal expression of E-cadherin plays an important role in the malignant progression of bladder tumor and can be used as an indicator to judge the malignant degree and prognosis of bladder tumor.