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氯丙嗪具有广泛药理作用,临床主要用于治疗精神病、各种原因引起的呕吐以及低温麻醉和人工冬眠等。近年来,其临床用途进展颇大,现综述如下. 一、治疗心力衰竭氯丙嗪可阻断α肾上腺素能受体而使血管扩张,特别是扩张静脉,故主要能降低心脏前负荷;其镇静止吐作用可减少心肌氧耗;此外,还可加强利尿剂的利尿效
Chlorpromazine has a wide range of pharmacological effects, clinical mainly for the treatment of mental illness, vomiting caused by various reasons and low temperature anesthesia and artificial hibernation. In recent years, its clinical use of considerable progress, are summarized as follows: First, the treatment of heart failure chlorpromazine can block alpha adrenergic receptors and vasodilation, especially the dilatation of the vein, it can reduce the pre-cardiac load; its Sedative antiemetic can reduce myocardial oxygen consumption; In addition, diuretic diuretic effect can be strengthened