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两项研究证实经阴道后穹窿置入 misoprostol对妊娠晚期诱导子宫收缩的效应:一项是剂量范围的研究;另一项是对本品和催产素的比较研究。第一项研究为孕龄在28～36周(组1,11例)或36周以上(组2,45例)的患者。引产有医学指征。本品经阴道后穹窿置入,起始剂量为50μg,随后每2小时增加剂量50μg 至获得满意子宫活动止,最大容许量为600μg。在8小时内分娩者认为引产成功。组1和组2分别有36%和69%是未产妇;8小时内分娩者分别为36%和73%;所需本品平均剂量
Two studies confirm the effect of transvaginal posterior fornix insertion of misoprostol on uterine contraction induced by late pregnancy: one is the dose range study; the other is a comparative study of this product and oxytocin. The first study included patients with gestational age of 28 to 36 weeks (group 1, 11) or 36 weeks (group 2, 45). Induction of medical indications. This product transvaginal posterior fornix into the initial dose of 50μg, then every 2 hours to increase the dose of 50μg to obtain satisfactory uterine activity only, the maximum allowable amount of 600μg. The childbirther thinks that the induction of labor is successful within 8 hours. 36% and 69% of group 1 and group 2, respectively, were unwanted mothers; 36% and 73% of those who delivered within 8 hours, respectively; and the average dose required