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原癌基因家族中的ｃ－ｆｏｓ在中枢神经系统中的表达与痛觉调节有关。本文利用免疫组织化学技术检测了在单侧移动大鼠磨牙时，三叉神经感觉核簇及延髓某些区域ＦＯＳ阳性神经元（ＦＬＮ）的分布，时程变化等。结果表明，ＦＬＮ密集分布于刺激同侧Ｖｃ的Ⅰ，Ⅱ层，在外侧网状核（ＬＲＴ）、孤束核（ＳＯＬ）等处也有较多的ＦＬＮ分布，ＦＩＮ在１ｈ组内开始出现、２ｈ达到高峰、４ｈ后开始减少、至１２ｈ、２４ｈ仍有少量表达。说明牙齿移动引发的疼痛不适在延髓的一些脑区得到调控，如何减轻这种疼痛不适值得进一步研究
The expression of c-fos in the proto-oncogene family in the central nervous system is related to the regulation of pain. In this paper, immunohistochemistry was used to detect the distribution and time course of FOS positive neurons (FLN) in the trigeminal sensory nucleus and some regions of the medulla oblongata during unilateral movement of rat molars. The results showed that FLN was densely distributed in layers Ⅰ and Ⅱ that stimulated ipsilateral Vc. There was also more FLN distribution in the lateral reticular nucleus (LRT) and solitary nucleus (SOL) Reached the peak, began to decrease 4h, to 12h, 24h still a small amount of expression. Indicating that the pain caused by tooth movement discomfort in the medulla oblongata some brain area regulation, how to reduce this pain discomfort deserves further study