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Sontag 及 Wallace(1935)发现孕妇开始吸一支烟后胎心率即增加,他归因于胎盘传递了尼吉丁。Campbell(1935)强调慢性尼古丁中毒是生殖力低的一个因素。烟癖产妇的低体重儿率二倍于不吸烟者(Simpson1957)。Phelan(1980)发现吸烟的孕妇对无刺激试验常无反应。Lehtovirta等(1983)观察了8例发现其胎心率基线也减少。
Sontag and Wallace (1935) found that the fetal heart rate increased after a pregnant woman started smoking a cigarette, which was attributed to the placenta. Campbell (1935) emphasized that chronic nicotine poisoning is a factor of low fertility. The prevalence of low birth weight babies was twice as high as that of nonsmokers (Simpson 1957). Phelan (1980) found that pregnant women who smoke are often unresponsive to non-irritating tests. Lehtovirta et al (1983) observed in 8 cases found that its fetal heart rate baseline also decreased.