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动物试验研究表明,某些中枢神经系统活性药物可影响脑局部损害后行为的恢复。甚至单一剂量就可导致长期不良作用。本项研究的目的是明确这些药物对人类是否也有相同的不良作用。 在研究GM_1神经节苷酯对缺血性卒中作用的多中心研究组中,选择参加Sygen急性卒中研究组(SASS)的对照患者作前瞻性研究。其标准为起病在48h内、颈动脉分布区的缺血性卒中的成人患者。在卒中后入院时、7、14、21、48、56及84天分别作Toronto卒中量表运动评分(TSSMS)评价运动障
Animal studies have shown that certain CNS active drugs can affect the recovery of behavior after local brain damage. Even a single dose can cause long-term adverse effects. The purpose of this study is to determine whether these drugs have the same adverse effects on humans. A prospective study of control patients enrolled in the Sygen Acute Stroke Study Group (SASS) was included in the multicenter study to investigate the effect of GM_1 ganglioside on ischemic stroke. The standard for onset in 48h, carotid artery distribution in ischemic stroke in adult patients. At stroke admission, the Toronto Stroke Scale Movement Rating (TSSMS) was assessed at 7, 14, 21, 48, 56, and 84 days for movement impairment