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目的 :探讨阿司匹林对脑梗死患者血同型半胱氨酸(Hcy)的影响。方法 :2012年1月~2013年12月于本院神经内科住院的脑梗死患者100例,随机分成非阿司匹林组50例,阿司匹林组50例。检测治疗前后患者血Hcy、hs-CRP水平,并采用美国国立卫生院神经功能缺损评分(NIHSS)对患者治疗前后生活质量评估。结果 :治疗后患者的血Hcy、hs-CRP水平明显降低,NISSH评分明显降低,血Hcy、hs-CRP水平与患者的NISSH评分呈正相关。治疗后阿司匹林组Hcy、hs-CRP水平较非阿司匹林组明显降低。治疗后阿司匹林组NISSH评分较非阿司匹林组降低,但无统计学意义。结论 :阿司匹林治疗后脑梗死患者血清同型半胱氨酸(Hcy)、hs-CRP水平降低,生活质量改善。
Objective: To investigate the effect of aspirin on blood homocysteine (Hcy) in patients with cerebral infarction. Methods: One hundred patients with cerebral infarction hospitalized in Department of Neurology from January 2012 to December 2013 were randomly divided into 50 cases in non-aspirin group and 50 cases in aspirin group. The levels of Hcy and hs-CRP in patients before and after treatment were measured. The quality of life of patients before and after treatment was evaluated by National Institutes of Health neurological deficit score (NIHSS). Results: After treatment, the levels of Hcy and hs-CRP were significantly decreased, the NISSH score was significantly lower, and the levels of Hcy and hs-CRP were positively correlated with the NISSH score. After treatment, the levels of Hcy and hs-CRP in aspirin group were significantly lower than those in non-aspirin group. After treatment, the NISSH score in aspirin group was lower than that in non-aspirin group, but there was no statistical significance. Conclusion: Serum homocysteine (Hcy) and hs-CRP level are decreased and quality of life is improved in patients with cerebral infarction after aspirin treatment.