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随着原发性肝细胞癌(PHCC)手术切除例数的增多,术后复发性肝细胞癌(RHCC)的发生率也有随之增多的趋势。国内报道PHCC术后5年RHCC的发生率约为60%,国外报道为70%~80%。探讨RHCC的发生机制。对于临床科学制定RHCC个体化治疗方案有实际的指导意义。1单克隆与多克隆起源模式对RHCC的起源问题早在20多年前就已经开始探讨,目前认为RHCC的发生主要有2种途径,一种是来自PHCC术后肝内残留癌细胞导致的复发型(intrahepatic me-
With the increase of surgical resection of primary hepatocellular carcinoma (PHCC), the incidence of postoperative recurrent hepatocellular carcinoma (RHCC) tends to increase. Domestic reports PHCC 5 years after the incidence of RHCC about 60%, 70% to 80% of foreign reports. To investigate the mechanism of RHCC. For clinical science to develop individualized treatment of RHCC program has practical significance. The Origin of Monoclonal and Polyclonal Origins The origins of RHCC have been discussed as early as 20 years ago. Currently, there are mainly two ways of RHCC occurrence, one is recurrence from residual intrahepatic cancer cells after PHCC (intrahepatic me-