A型肉毒毒素目前在皮肤科主要被用于改善动态皱纹、咬肌肥大及牙龈外露等美容领域,由于其良好的安全性,近年来越来越多的研究将其用于皮肤科疾病的治疗,如:多汗症、腋臭、带状疱疹后遗神经痛等疾病.但国内关于A型肉毒毒素对皮肤附属器疾病治疗作用的研究还较少,本文通过回顾近年来相关研究,从不同疾病的发病机制、A型肉毒毒素治疗机制以及治疗方法几个方面进行综述.“,”Botulinum toxin type A have been mainly used in cosmetic dermatology such as dynamic wrinkle, masseter hypertrophy and gummy smile. In recently years, it is increasingly applied in treating some skin disease, such as hyperhidrosis, osmidrosis and post-herpetic neuralgia. But there are few discussion about botulinum toxin therapy in appendages disorders. We reviewed the associative researches, and describes the pathogenesis, possible therapeutic mechanisms and therapies.