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测定甾体激素的内分泌功能,通常采用尿或血浆作为分析样本,但采样受到时间、场合等多种限制。现在发展了一种从唾液测定体内甾体激素的新方法,取样快而简便,病人不感到紧张和负担,可以在短时间内多次取样,重复性好,适用于短期动力学观察及长期生物学变化的研究。另外,由于唾液中缺乏特异的和非特异的结合蛋白,故可简化激素的测定步骤,发展非提取的直接测定法,使测定的时间缩短,结果准确。
Determination of steroid hormone endocrine function, usually using urine or plasma as the analysis of samples, but by sampling time, occasions and other restrictions. Now developed a new method for the determination of steroid hormones in the body from saliva, sampling quick and easy, the patient does not feel nervous and the burden of multiple samples can be repeated in a short time, good repeatability, suitable for short-term kinetic observations and long-term biological Study of change. In addition, due to the absence of specific and nonspecific binding proteins in saliva, it is possible to simplify the determination of hormones and to develop a non-extraction direct assay to shorten the assay time with accurate results.