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目的：研究舒芬太尼联合依托咪酯在门诊无痛胃肠镜检查麻醉中的最佳用药间隔时间。方法选取梧州市红十字会医院内镜室2014年10月—2015年10月行无痛胃肠镜检查患者160例，根据用药间隔时间不同分为A组、B组、C组和D组，各40例。均给予舒芬太尼0.1μg/kg，依托酯首次剂量0.15~0.20mg/kg，均在30s内注完，其中A组患者注入舒芬太尼后间隔0~2min注入依托咪酯；B组间隔2~5min；C组间隔5~10min；D组间隔10min以上。观察记录4组患者入室后和给药后的血压、心率、SpO2、肌颤情况、入镜反应、体动反应、皱眉、舒芬太尼和依托咪酯用量、操作时间、睁眼时间及不良反应等指标。结果4组患者各组内部血压、心率和SpO2的最低值与基础值比较，差异无统计学意义（ P﹥0.05），且各组间血压、心率的下降幅度均小于基础值的20％，处于参考范围内。4组患者血压、心率和SpO2的最低值比较，差异无统计学意义（ P﹥0.05）。A组患者肌颤发生率高于D组， B组肌颤发生率低于C组，C组肌颤发生率高于D组（ P﹤0.05）。且B组和D组的肌颤程度相对较轻（ P﹥0.05）。4组患者入镜反应发生率、术中体动反应发生率、皱眉发生率比较，差异无统计学意义（ P﹥0.05），且任何组别两两比较，差异无统计学意义（ P﹥0.05）。4组患者依托咪酯的首量和追加量、舒芬太尼用量比较，差异无统计学意义（P﹥0.05），其中A组依托咪酯首量高于C组（P﹤0.05）。4组患者操作时间及睁眼时间、术中知晓率、术后不良反应比较，差异无统计学意义（ P﹥0.05）。结论在无痛胃肠镜麻醉中，先给予舒芬太尼后间隔2~5min再注入依托咪酯，对呼吸、血液循环系统抑制轻，可减轻入镜时的刺激，预防肌颤效果佳，体动反应、皱眉发生程度轻，患者苏醒迅速，几乎无术中记忆，头晕、恶心呕吐等不良反应发生率也较低，患者总体感觉良好。“,”Objective To study the best dosage interval time of sufentanil combined with etomidate on painless stom-ach and colonoscopy anesthesia. Methods A total of 160 patients who accepted painless stomach and colonoscopy examination were selected from October 2014 to October 2015,which were divided into A,B,C,D group according to the interval time of medicine,40 cases in each group. All patients were given sufentanil 0. 1μg/kg,and the first dose of etomidate was 0. 15 -0. 2mg/kg within 30s. The A group was injected with sufentanil,then treated with etomidate interval 0-2min,B group of dos-age interval time was 2-5min,C group of dosage interval time was 5-10min,D group of dosage interval time was 10min later. The blood pressure, heart rate, SpO2 , muscle fibrillation, her reaction, body dynamic reaction, frowning, the dosage of sufentanil and etomidate,operation time,opening eyes time and adverse reactions among four groups were observed and recor-ded. Results There was no stutistically significant differences in the lowest value and baseline value of blood pressure,heart rate and SpO2 among four groups(P﹥0. 05),the decreased range of blood pressure and heart rate were less than 20% of the baseline value,which were in reference rangegree. There was no differences in the lowest value of blood pressure,heart rate and SpO2(P﹥0. 05). The incidence rate of myoclonus of A group was higher than D group,B group was lower than C group, C group was higher than D group(P﹤0. 05). There was no differences in myoclonus between B and D groups(P﹥0. 05). There was no differences in incidence rate of her reaction,body dynamic reaction or frowning among four groups(P﹥0. 05), there was no statistically significant differences of any two group compared(P﹥0. 05). There was no differences in dosage of sufentanil and etomidate among four groups(P﹥0. 05),the A group of first dosage of etomidate was higher than C group(P﹤0. 05). There was no differences in operation time or opening eyes time,intraoperative awareness rate or adverse reactions a-mong four groups(P﹥0. 05). Conclusion During painless stomach and colonoscopy anesthesia,giving etomidate interval 2 -5min of sufentanil injection,inhibition for breathing and circulation is light,while that for the stimulation to tendoscopy is strong,the effect of myoclonus preventation is best,body dynamic reaction and frowning are light,and the incidence rate of ad-verse reactions are low,so the patients revive rapidly,almost have no memory,patients feel good in general.