目的探讨Dukes B期结直肠癌临床病理特征及预后的关系,以指导术后选择性辅助化疗。方法收集1990~1999年416例根治性切除的Dukes B期结直肠癌病例临床资料,采用单因素和多因素分析的方法,研究B期结直肠癌患者预后的影响因素。结果单因素分析显示,活动程度、肠壁侵袭层次、术中输血及术中化疗与预后有关。Cox比例危险回归模型多因素分析显示,仅活动程度、肠壁侵袭层次及术中输血是预后的独立影响因素。结论活动程度、肠壁侵袭层次及术中输血是Dukes B期结直肠癌预后的独立影响因素,可作为Dukes B期患者选择性进行辅助化疗的参考。 Objective To investigate the relationship between the clinicopathological features and prognosis of Dukes B colorectal cancer so as to guide selective adjuvant chemotherapy. Methods The clinical data of 416 cases of radical resection of Dukes B colorectal cancer from 1990 to 1999 were collected. Univariate and multivariate analysis methods were used to study the prognostic factors in patients with stage B colorectal cancer. Results Univariate analysis showed that the degree of activity, the level of intestinal invasion, intraoperative blood transfusion, and intraoperative chemotherapy were related to prognosis. Cox proportional hazards regression model multivariate analysis showed that only the degree of activity, intestinal invasion level and intraoperative blood transfusion were independent prognostic factors. Conclusions The degree of activity, the level of intestinal invasion, and intraoperative blood transfusion are independent prognostic factors of Dukes B colorectal cancer and can be used as a reference for selective adjuvant chemotherapy in Dukes B patients.