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目的观察根除幽门螺杆菌（ＨＰ）对老年人十二指肠溃疡（ＤＵ）再出血的影响。方法７０例老年人ＤＵ并出血患者分成两组。Ａ组用洛赛克、德诺和羟氨苄青霉素根除ＨＰ，Ｂ组单独用洛赛克治疗。４ｗ后停药随访１８个月。结果两组溃疡愈合率分别为１００．０％、９６．７％，无显著差异（Ｐ＞０．０５）。Ａ组ＨＰ根除率（８５．０％）显著高于Ｂ组（１６．６％）（Ｐ＜０．０５）。１８个月后，Ａ、Ｂ两组再出血率分别为２．９４％和２８．００％，前者显著低于后者（Ｐ＜０．０５）。结论根除ＨＰ对老年人ＤＵ再出血有预防作用。
Objective To observe the effect of eradication of Helicobacter pylori (HP) on rebleeding of duodenal ulcer (DU) in the elderly. Methods 70 elderly patients with DU and bleeding were divided into two groups. Group A was treated with Losec, de Novo and Amoxicillin to eradicate HP, and Group B with Losec alone. 4w after stopping for 18 months. Results The ulcer healing rates in both groups were 100.0% and 96.7%, respectively, with no significant difference (P> 0.05). The eradication rate of HP in group A (85.0%) was significantly higher than that in group B (16.6%) (P <0.05). After 18 months, the rebleeding rates of A and B groups were 2.94% and 28.00% respectively, the former was significantly lower than the latter (P <0.05). Conclusions Eradication of HP can prevent DU rebleeding in the elderly.