目的研究紫金胶囊对Ｄ氨基半乳糖（ＤＧｌａＮ）致大鼠肝损伤的保护作用．方法Ｗｉｓｔａｒ大鼠造型：ＤＧｌａＮ（０８ｇ／ｋｇ），ｉｐ，１次／ｄ，连续２ｄ；生理盐水１０ｍｌ／ｋｇ，ｉｇ，２次／ｄ，连续３ｄ．设空白组，单纯中药组（１４１ｇ／ｋｇ），联苯双酯（４０５ｍｇ／ｋｇ）阳性对照组，紫金胶囊低、中、高剂量组（２８、１４１、２２６ｇ／ｋｇ）．自动生化分析仪上检测血清的总胆红素含量、凝血酶原时间、总蛋白含量、白蛋白含量及ＡＬＴ活性，组间对比ｔ检验．观察形态结构，作肝小叶百分比、肝细胞索百分比、存活肝细胞核和慢性炎细胞核的形态计量，组间对比ｑ检验或ｔ检验．结果紫金胶囊明显降低血清总胆红素含量（μｍｏｌ／Ｌ，从５７６±４９到７２±０９以下），缩短凝血酶原时间（ｓ，从１３８５±１２５到１０４６±３４以下），升高血清总蛋白含量（ｇ／Ｌ，从４９２±２２到５７２±２１以上），升高血清白蛋白含量（ｇ／Ｌ，从３００±１６到３９７±１７以上）及降低血清ＡＬＴ活性（μｍｏｌ／ｍｉｎ，从３３７４±９５３到８９３±１５３以下）；紫金胶囊明显降低肝小叶百分比（从７３７到７１２以下）和降低肝? Objective To study the protective effect of Zijin capsule on liver injury induced by DGalaN in rats. Methods Wistar rats were stained with DGlaN (08 g / kg) ip for 1 d / d for 2 d, and saline 10 ml / kg ig for 2 d for 3 d. The rats in the blank group were treated with the traditional Chinese medicine group (141g / kg), the bifendate (405mg / kg) positive control group, the Zijin capsule low, middle and high dose group (28,141,22 6g / kg). Serum total bilirubin, prothrombin time, total protein content, albumin content and ALT activity were detected on automatic biochemical analyzer. Observed the morphological structure, the percentage of hepatic lobule, the percentage of hepatocellular cord, the morphology of the surviving hepatocyte nucleus and the chronic inflammatory cell nucleus were measured by q test or t test. Results Zijin capsule significantly reduced serum total bilirubin (μmol / L, from 57  6 ± 4  9 to 7  2 ± 0  9 or less), shortening prothrombin time (s, from 1385 ± 125 to 1046 ± 34), increase the serum total protein (g / L, from 49.2 ± 22 to 572 ± 21), increase the content of serum albumin (g / L, from 30 ± 0 1  6 to 39  7 ± 1  7 above) and reduce serum ALT activity (μmol / min, from 337  95 ± 3 to 89  3 ± 15  3 below); Zijin capsule significantly reduce the percentage of hepatic lobules ( From 73  7 to 71  2 the following) and reduce the liver?