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目的:观察治伤软膏局部外敷对急性软组织损伤模型大鼠的治疗效果,并探讨其作用机理。方法:将30只SD大鼠制成动物模型,随机分为治疗组(A)、对照组(B),A组用治伤软膏外敷治疗,B组空白对照。用药第3、5、10d作大体观察、光镜下组织观察、血液流变检测。结果:两组大体观察各时相评分比较差异无统计学意义(P>0.05);第5d A组组织病理革兰氏染色评分优于B组(P<0.01);血液流变学检测显示A组用药后各时相全血粘度(低、中切)、红细胞压积、全血还原粘度(低切)都明显低于B组(P<0.01)。结论:治伤软膏外用治疗急性血瘀证模型大鼠,能明显降低血液粘度、改善其血液流变性,促进损伤组织的修复。
OBJECTIVE: To observe the therapeutic effect of local application of Zhishang Ointment on rats with acute soft tissue injury and to explore its mechanism of action. METHODS: Thirty SD rats were made into animal models and randomly divided into treatment group (A) and control group (B). Group A was treated with Zhizheng Ointment with external application, and group B blank control. The 3rd, 5th, and 10th days of medication were used for general observation, light microscopy, and blood rheology. Results: There was no significant difference in the scores of the two groups at all time points (P>0.05). The score of histopathological Gram stain was better in the 5d group A than in the group B (P<0.01). Hemorheology test showed A. After treatment, the blood viscosity (low and medium cut), hematocrit, and reduced viscosity (low cut) of whole blood were significantly lower in group B than in group B (P<0.01). Conclusion: Zhishen ointment can effectively reduce blood viscosity, improve blood rheology, and promote the repair of damaged tissue in rats with acute blood stasis syndrome.