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目的了解杭州市不同妊娠期妇女尿碘与尿肌酐水平,为指导妊娠妇女科学补碘提供依据。方法采用酸消化砷-铈接触法检测水碘、尿碘;苦味酸法测定尿肌酐;硫代硫酸钠法测定盐碘。结果妊娠早、中、晚期妇女尿碘中位数分别为171.30μg/L、167.35μg/L、162.40μg/L,均明显低于对照组(251.90μg/L)(Z=-2.315,P=0.021;Z=-4.352,P=0.000;Z=-3.704,P=0.000);妊娠早、中、晚期妇女尿碘值<150μg/L比例分别占40.0%、45.1%、43.3%,其比例显著高于对照组(24.2%)(χ~2=5.551,P=0.018;χ~2=9.226,P=0.002;χ~2= 7.647,P=0.006);妊娠早、中、晚期妇女尿肌酐均值分别为1.37 g/L、0.97 g/L、0.81 g/L,均显著低于对照组(1.68 g/L)(P<0.05),且妊娠中、晚期妇女尿肌酐水平显著低于妊娠早期(P<0.05)。结论杭州市碘盐供应良好,妊娠妇女总体尿碘水平处于适宜范围,但随着孕龄的增加,尿碘和尿肌酐水平依次下降,妊娠中、晚期妇女更易发生碘营养不足;妊娠妇女需在食用碘盐基础上,定期进行碘营养监测,科学补碘。
Objective To understand the levels of urinary iodine and urinary creatinine in different pregnant women in Hangzhou and to provide basis for guiding scientific iodine supplementation in pregnant women. Methods Acid arsenic - cerium contact method was used to detect water iodine and urinary iodine; picric acid method was used to measure urinary creatinine; sodium thiosulfate method was used to determine salt and iodine. Results The median urinary iodine in early, middle and late pregnancy were 171.30μg / L, 167.35μg / L and 162.40μg / L respectively, which were significantly lower than those in control group (251.90μg / L, Z = -2.315, P = The proportion of urinary iodine <150μg / L in women with early, middle and late pregnancy accounted for 40.0%, 45.1% and 43.3%, respectively, with a significant proportion (24.2%) in the control group (χ ~ 2 = 5.551, P = 0.018; χ ~ 2 = 9.226, P = 0.002; χ ~ 2 = 7.647, P = 0.006) (1.37 g / L, 0.97 g / L and 0.81 g / L, respectively), which were significantly lower than those in the control group (1.68 g / L, P 0. 05). Urinary creatinine levels in the third and third trimester women were significantly lower than those in the first trimester P <0.05). Conclusions The supply of iodized salt in Hangzhou is good and the total urinary iodine level in pregnant women is in the suitable range. However, with the increase of gestational age, urinary iodine and urinary creatinine levels decline in turn, and women in middle and late pregnancy are more likely to suffer from iodine deficiency. On the basis of consumption of iodized salt, regular iodine nutrition monitoring, scientific iodine.