论文部分内容阅读
目的分析探讨小剂量干扰素治疗丙型肝炎(丙肝)病毒核糖核酸(HCV-RNA)阳性丙肝肝硬化的临床效果。方法 74例HCV-RNA阳性丙肝肝硬化患者,随机分为对照组和治疗组,各37例。对照组给予常规保肝治疗,治疗组在此基础上采用小剂量干扰素治疗,对比分析两组的临床疗效。结果治疗后,治疗组血清丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)改善情况以及临床疗效明显优于对照组,差异均有统计学意义(P<0.05)。结论采用小剂量干扰素治疗HCV-RNA阳性丙肝肝硬化,能够使血清HCV-RNA转为阴性,改善临床症状及肝功能,提高治疗效果,值得临床推广使用。
Objective To investigate the clinical efficacy of low-dose interferon in the treatment of hepatitis C virus (HCV) positive hepatitis C cirrhosis. Methods Totally 74 patients with HCV-RNA positive hepatitis C cirrhosis were randomly divided into control group and treatment group, 37 cases in each group. The control group was given routine hepatoprotective therapy, and the treatment group was treated with low-dose interferon on the basis of this analysis. The clinical efficacy of the two groups were compared. Results After treatment, the improvement of serum alanine aminotransferase (ALT) and total bilirubin (TBIL) and the clinical curative effect in the treatment group were significantly better than those in the control group, with significant differences (P <0.05). Conclusion Low-dose interferon treatment of HCV-RNA-positive hepatitis C cirrhosis can turn serum HCV-RNA negative, improve clinical symptoms and liver function, and improve the therapeutic effect, which is worthy of clinical promotion.