手足口病(hand-foot-and-mouth disease)于1957年在新西兰首次报道以来,目前在世界大部分地区均有流行报道,属于全球性的传染病。1958年加拿大人首次从手足口病患者中分离出致病病毒——柯萨奇病毒~([1]),1959年正式提出以手足口病“命名。随后发生多次手足口的流行~([2,3])。我国首次在1981年上海爆发手足口病以来脯后北京、河北、天津、福建、吉林、山东、湖北、青海、广东、河南等十几个省市均有报 Hand-foot-and-mouth disease, first reported in New Zealand in 1957, is now endemic in most parts of the world and is a globally contagious disease. 1958 Canadian for the first time isolated from patients with hand-foot-mouth disease virus - Coxsackie virus ~ ([1]), 1959 formally proposed hand-foot-mouth disease ”name. Followed by multiple hand-foot-mouth epidemic ~ ([2, 3]) .For the first time in China since the outbreak of hand-foot-mouth disease in Shanghai in 1981, more than 10 provinces and cities such as Beijing, Hebei, Tianjin, Fujian, Jilin, Shandong, Hubei, Qinghai, Guangdong and Henan have been reported