组织蛋白酶S(CatS)属于溶酶体半胱氨酸蛋白酶家族的一员,在中性、酸性环境下均具有较高的稳定性,它可降解细胞内外正常蛋白质,广泛参与抗原递呈、细胞增殖、创伤修复、血管生成、免疫及炎症反应等病理生理过程.据报道,CatS在动脉粥样硬化、动脉瘤及新生血管形成方面具有重要作用.本研究就CatS与心血管疾病相关性方面的研究进展进行了综述. Cathepsin S (CatS) belongs to a member of the lysosomal cysteine ​​protease family and has high stability in both neutral and acidic environments. It can degrade the normal proteins inside and outside the cell and is widely involved in antigen presentation. Cells Proliferation, wound healing, angiogenesis, immune and inflammatory response and other pathophysiological processes.Reportedly, CatS plays an important role in atherosclerosis, aneurysm and neovascularization.In this study, the relationship between CatS and cardiovascular diseases The research progress is reviewed.