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本文报告黄连素与放射配基3H-prazosin和3H-DHA竞争结合α_1受体和β_1受体的实验。结果显示黄连素对α-1受体具有很强的亲和力(IC50为4.15×10~(-7),其作用强度与经典的酚妥拉明相似(IC50为2.65×10~(-1)M);对β受体具有微弱的亲和力(IC50为1.59×10~(-5)M)。上述结果提示黄连素可通过α受体及β受体而产生药理作用。
In this paper, we report that Berberine competes with 3H-DHA and 3H-DHA for the binding of α 1 receptor and β 1 receptor. The results showed that berberine has a strong affinity for α-1 receptor (IC50 is 4.15 × 10 -7, and its intensity of action is similar to the classic phentolamine (IC50 is 2.65 × 10 ~ (-1) M ), Weak affinity for β receptor (IC50 1.59 × 10 -5 M) .The above results suggest that berberine can exert pharmacological effects through α receptor and β receptor.