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目的观察慢性粒细胞性白血病(CML)患者血清尿酸与乳酸脱氢酶浓度变化及与正常人浓度的对比分析。方法按病例对照研究方法,设试验组6例CML患者,对照组20例健康体检者,分别测定两组尿酸及乳酸脱氢酶水平,进行统计学分析。结果 CML患者尿酸及乳酸脱氢酶水平明显高于正常者。结论 CML患者血清尿酸与乳酸脱氢酶明显高于正常者,反映了患者体内白血病细胞的负荷,可用于CML的诊断依据。
Objective To observe the changes of serum uric acid and lactate dehydrogenase in patients with chronic myeloid leukemia (CML) and compare with those in normal people. Methods According to the case-control study, six patients with CML in the test group and 20 healthy subjects in the control group were enrolled. The level of uric acid and lactate dehydrogenase in the two groups were measured and statistically analyzed. Results CML patients with uric acid and lactate dehydrogenase levels were significantly higher than normal. Conclusions Serum uric acid and lactate dehydrogenase in CML patients were significantly higher than those in normal subjects, reflecting the load of leukemic cells in patients with CML, which could be used to diagnose CML.