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目的:观察早泄患者精浆生化指标的变化,探讨其与早泄的关系。方法:根据WHO对早泄的定义,随机选取56例早泄患者,及无早泄正常生育男性60例作为对照。留取各自精液,分离精浆后,分别测定精浆α-葡萄糖苷酶(α-Glu)、酸性磷酸酶(ACP)和果糖(Fru)。结果:早泄组精浆中ACP、α-Glu和Fru的含量分别为:(36.37±31.33)U/ml、(39.97±22.09)U/ml、(3.40±1.92)mg/ml,与对照组(54.27±20.96)U/ml、(55.71±16.19)U/ml及(2.55±1.12)mg/ml相比,精浆中ACP、α-Glu的含量明显降低(P<0.01和P<0.05)。而精浆中Fru的含量两组相比无显著差异(P>0.05)。ACP合并α-Glu含量异常者,早泄组为31%,对照组为13%,两组相比有显著差异(P<0.05);ACP、α-Glu和Fru含量均正常者,早泄组为10%,对照组为33%,两组相比也有显著差异(P<0.05)。结论:早泄患者精浆ACP和α-Glu含量明显低于无早泄者,提示临床诊治早泄时,考虑前列腺和附睾功能异常并进行治疗,可能是治疗早泄的一个新途径。
OBJECTIVE: To observe the changes of seminal plasma biochemical parameters in premature ejaculation and explore its relationship with premature ejaculation. Methods: According to the WHO definition of premature ejaculation, 56 cases of premature ejaculation were randomly selected and 60 cases of normal fertile men without premature ejaculation as control. After semen was collected and seminal plasma was separated, seminal plasma α-glucosidase (α-Glu), acid phosphatase (ACP) and fructose (Fru) were measured. Results: The contents of ACP, α-Glu and Fru in seminal plasma of premature ejaculation group were (36.37 ± 31.33) U / ml, (39.97 ± 22.09) U / ml and (3.40 ± 1.92) mg / The levels of ACP and α-Glu in the seminal plasma were significantly lower than those in the seminal plasma (P <0.01 and P <0.05) compared with the control group (54.27 ± 20.96) U / ml, (55.71 ± 16.19) U / ml and (2.55 ± 1.12) mg / ml. However, there was no significant difference in Fru content between the two groups (P> 0.05). ACP with α-Glu content were abnormal, premature ejaculation group was 31%, control group was 13%, there was significant difference between the two groups (P <0.05); ACP, α-Glu and Fru content were normal premature ejaculation group was 10 %, The control group was 33%, there was significant difference between the two groups (P <0.05). Conclusion: The content of ACP and α-Glu in seminal fluid of patients with premature ejaculation is significantly lower than those without premature ejaculation, suggesting that considering the dysfunction of prostate and epididymis in the treatment of premature ejaculation, it may be a new way to treat premature ejaculation.