神经肌肉接头作为突触解剖、生理和发育的模型已被研究了一个多世纪。成像技术提供了诸多关于神经肌肉接头的信息,其中一些技术是专为观察该突触的结构和功能而发展起来的。本文回顾了神经肌肉接头研究中几个重要方面的发展史,包括其结构、N型乙酰胆碱受体的分布、突触小泡释放,以及神经肌肉接头的发育。 Neuromuscular junctions have been studied for more than a century as models of synaptic anatomy, physiology and development. Imaging provides a wealth of information about neuromuscular junctions, some of which were developed specifically to look at the structure and function of the synapse. This article reviews the history of several important aspects of neuromuscular junction research, including its structure, N-acetylcholine receptor distribution, synaptic vesicle release, and neuromuscular junction development.