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肿瘤抗原基因MAGEs自被发现以来备受肿瘤免疫治疗研究者的关注。MAGE基因家族在非恶性组织中不表达,但在多数恶性肿瘤中发现表达。MAGE抗原是第一个被发现的肿瘤特异性抗原,可利用MAGE进行恶性肿瘤的免疫治疗,部分已应用于肿瘤免疫治疗的临床试验。
Tumor antigen gene MAGEs since its discovery has been the concern of tumor immunotherapy researchers. The MAGE gene family is not expressed in non-malignant tissues but is found in most malignancies. MAGE antigen is the first tumor-specific antigen that has been found to be able to utilize MAGE for immunotherapy of malignant tumors and has been used in some clinical trials for tumor immunotherapy.