目的 :观察厄贝沙坦 (Irbsartan ,Irb)及Irb联用氢氯噻嗪和 (或 )美托洛尔对原发性高血压的疗效。方法 :选择未经治疗或停服降压药 2周以上的高血压病各 96例 ,分设单用组 (厄贝沙坦组 )和联用组 [联用氢氯噻嗪和 (或 )美托洛尔组 ],总疗程 12周。用药前后做心电图、血尿常规、肝肾功能、血脂、血糖检查。治疗前及治疗 12周分别做 2 4hABPM。结果 :单用组总有效率 76 1% ,联用组达 10 0 % (P <0 0 1)。 2 4hABPM血压控制在理想水平 (P <0 0 1) ,且降压药物谷峰比值 (T/P)≥ 70 %。头昏、头痛、胸闷及心慌症状明显改善。治疗前后心电图、血尿常规、肝肾功能、血脂、血糖差异不显著 (P >0 0 5 ) ;对心率无明显影响 (P>0 0 5 )。结论 :Irb治疗轻、中度原发性高血压疗效确切 ,作用时间长 ,耐受性良好 ;联用氢氯噻嗪和 (或 )美托洛尔疗效优于单用厄贝沙坦 Objective: To observe the curative effect of Irbesartan (Irb) and Irb combined with hydrochlorothiazide and metoprolol on essential hypertension. Methods: Ninety-six patients with hypertension who were treated with or without antihypertensive drugs for more than 2 weeks were divided into single-use group (irbesartan group) and combination group (combined with hydrochlorothiazide and metoprolol Group], the total course of 12 weeks. ECG before and after treatment, hematuria, liver and kidney function, blood lipids, blood sugar check. Before treatment and 12 weeks of treatment were done 24hABPM. Results: The total effective rate was 76 1% in combination group and 100% in combined group (P <0.01). The blood pressure at 24 hABPM was controlled at the ideal level (P <0.01), and the trough-peak ratio (T / P) of antihypertensive drugs was ≥70%. Dizziness, headache, chest tightness and palpitation symptoms improved significantly. ECG before and after treatment, hematuria, liver and kidney function, blood lipids, blood glucose was no significant difference (P> 0 05); no significant effect on heart rate (P gt; 0 05). Conclusion: Irb treatment of mild to moderate essential hypertension is effective, long-acting and well tolerated; combination of hydrochlorothiazide and metoprolol is superior to irbesartan alone