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目的利用不同工艺制备姜黄素固体分散体,并对各姜黄素固体分散体的性质进行比较研究。方法主要通过冷冻干燥法、共沉淀法和微波淬冷法制备姜黄素/泊洛沙姆407固体分散体,利用扫描电镜(SEM)、差式扫描量热(DSC)、粉末X射线衍射(XRD)和傅里叶变换红外光谱(FT-IR)对所得固体分散体进行内在性质分析,通过溶出及溶解度实验来研究各工艺所得固体分散体改善药物难溶性质的特征。结果各工艺所得固体分散体内部药物以微晶形式存在,微波淬冷法比其他方法能更显著地改善姜黄素的溶出及溶解度。结论本实验为难溶性中药姜黄素固体分散体的实际生产工艺选择提供参考。
Objective To prepare curcumin solid dispersions by different techniques and to compare the properties of curcumin solid dispersions. Methods The curcumin / poloxamer 407 solid dispersions were prepared by freeze-drying, coprecipitation and microwave quenching methods. The morphology and structure of curcumin / poloxamer 407 were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction ) And Fourier Transform Infrared Spectroscopy (FT-IR) were used to analyze the intrinsic properties of the obtained solid dispersions. The dissolution and solubility experiments were carried out to study the characteristics of the solid dispersions obtained from each process. Results The internal medicine of the solid dispersion obtained by each process existed as microcrystals. The microwave quenching method could significantly improve the dissolution and solubility of curcumin than other methods. Conclusion This experiment for the insoluble solid curcumin solid dispersion of the actual production process to provide a reference.