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本文对比观察阿糖腺苷对慢性乙型肝炎病毒感染,伴 HBsAg 和 HBeAg 阳性以及 HBsAg 和抗 HBe 阳性者的乙型肝炎病毒复制、血清病毒蛋白浓度和肝功能的影响。研究对象为 HBsAg 阳性持续6个月、肝活检为慢性肝病者。其中治疗组13例,对照组11例。治疗组中7例患者 DNA 多聚酶升高、HBeAg 阳性,6例 DNA 多聚酶阴性、抗 HBe 阳性。对照组6例DNA 多聚酶升高,5例 DNA 多聚酶阴性。3例有肝肿大,4例订肝脾肿大,其中2例有腹水。治疗组应用阿糖腺苷溶于5%葡萄糖液中静脉注射。开始应用10～15mg/kg/d,治疗5天,第2周亦5天。3例 HBeAg 阳性者在第3～4月后给以大剂量阿糖腺苷。对照组应用5%葡萄糖静脉治疗。治
In this paper, we compared the effects of adenosine on hepatitis B virus replication, serum viral protein concentration and liver function in patients with chronic hepatitis B virus infection, HBsAg and HBeAg positive, and HBsAg and HBeAg positive. The subjects were HBsAg positive for 6 months and liver biopsy for chronic liver disease. Among them, 13 cases in the treatment group and 11 cases in the control group. In the treatment group, 7 cases of patients with DNA polymerase increased, HBeAg positive, 6 cases of DNA polymerase negative, anti-HBe positive. The control group, 6 cases of DNA polymerase increased, 5 cases of DNA polymerase negative. 3 cases of hepatomegaly, 4 cases of hepatosplenomegaly, of which 2 cases had ascites. Treatment group application of adenosine dissolved in 5% glucose solution intravenous injection. The initial application of 10 ~ 15mg / kg / d, treatment for 5 days, the second week also 5 days. Three HBeAg-positive patients were given large doses of arabinoside after 3 to 4 months. Control group with 5% glucose intravenous therapy. rule