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为观察高原对大鼠血浆与组织６一Ｋｅｔｏ一ＰＧＦ＿（１α）和ＴＸＢ＿２含量的影响及丹参的保护作用。采用３Ｈ一ＴＸＢ＿２及３Ｈ－６一Ｋｅｔｏ一ＰＧＦ＿（１α）药盒及方法。结果：平原大鼠进入海拔４４７５ｍ高原后，其心、肝、脾脏组织及血浆中血栓素Ｂ＿２（ＴＸＢ＿２）含量显著升高（Ｐ＜０．０５）；心脏和血浆中６一酮一前列腺素Ｆ＿（１α）（６一Ｋｅｔｏ一ＰＧＦ＿（１α））含量则显著降低（Ｐ＜０．０１）；各项Ｔ／Ｋ比值均显著增大（Ｐ＜０．０１），丹参合剂能有效地预防高原低氧环境对大鼠的上述影响（Ｐ＜０．０５或Ｐ＜０．０１）。提示该药用于防治而原疾病值得深入研究。
To observe the plateau on the plasma and tissue 6-Keto-PGF_ (1α) and TXB_2 levels and the protective effect of Salvia miltiorrhiza. 3H-TXB_2 and 3H-6-Keto-PGF_ (1α) kit and method were used. Results: The content of TXB_2 in the heart, liver, spleen and plasma was significantly increased in plain rats after entering the altitude of 4475m (P <0.05). The levels of 6-keto-PGF_ (1α) (6-Keto-PGF_ (1α)) was significantly decreased (P <0.01), and the ratio of T / K increased significantly (P <0.01). Salvia miltiorrhiza mixture could effectively prevent plateau The above effects of hypoxic environment on rats (P <0.05 or P <0.01). Suggesting that the drug used for prevention and treatment of the original disease worth further study.