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目的探讨α-硫辛酸联合依达拉奉注射液治疗急性脑梗死(ACI)的临床疗效。方法 96例ACI患者按随机数字表分为观察组和对照组,每组48例。在常规治疗基础上,观察组使用α-硫辛酸联合依达拉奉注射液治疗,对照组仅使用依达拉奉治疗,14 d为1个疗程,观察并比较两组的疗效和不良反应。结果观察组总有效率为97.9%(47/48),对照组总有效率为87.5%(42/48),比较差异有统计学意义(P<0.05)。两组药物不良反应少见。结论α-硫辛酸联合依达拉奉注射液治疗急性脑梗死疗效显著,且安全性较高。
Objective To investigate the clinical efficacy of α-lipoic acid combined with edaravone in the treatment of acute cerebral infarction (ACI). Methods 96 cases of ACI patients according to random number table divided into observation group and control group, 48 cases in each group. On the basis of routine treatment, the observation group was treated with α-lipoic acid combined with edaravone. The control group was treated with edaravone only for 14 days. One course of treatment was observed on the 14th day. Efficacy and adverse reactions of the two groups were observed and compared. Results The total effective rate was 97.9% (47/48) in the observation group and 87.5% (42/48) in the control group, with statistical significance (P <0.05). Two groups of adverse drug reactions rare. Conclusion The combination of α-lipoic acid and edaravone in the treatment of acute cerebral infarction has obvious curative effect and high safety.