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目的探讨术前介入治疗对肝癌肿瘤浸润淋巴细胞的影响。方法 13例肝癌患者分成 2组 ,7例接受术前介入治疗者为实验组 ,6例未接受术前化疗者为对照组。体外培养 ,检测TIL细胞、抗肿瘤活性、表型。结果实验组TIL细胞在第 2周达到高峰 ,至第 3周平均扩增 5 2倍 ,而对照组在第 3周扩增达到高峰 ,平均扩增了 12倍。术前介入化疗患者TIL细胞肿瘤杀伤活性增强 ,CD+ 3 、CD+ 4 、CD+ 8不同程度的增加。结论术前介入化疗可缩短肝癌患者TIL细胞增殖时间 ,提高肿瘤杀伤活性。
Objective To investigate the effect of preoperative intervention on tumor infiltrating lymphocytes in liver cancer. Methods Thirteen patients with hepatocellular carcinoma were divided into two groups. Seven patients underwent preoperative intervention as experimental group and six patients who did not receive preoperative chemotherapy as control group. In vitro culture, TIL cells were detected, anti-tumor activity, phenotype. Results The number of TIL cells in experimental group peaked at the second week, reached an average of 52% in the third week, while the control group reached its peak at the third week with an average of 12-fold amplification. Preoperative interventional chemotherapy patients TIL cell tumor activity increased, CD +3, CD +4, CD +8 increased in varying degrees. Conclusion Preoperative chemotherapy can shorten the proliferation of TIL cells in patients with hepatocellular carcinoma and improve the tumor killing activity.