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实验观察给予13名受试者皮下注射可乐宁等0.1ml对局部出汗率、局部活动汗腺数、局部光电脉搏波与局部皮肤温度等指标的影响。发现(1)在给药局部可乐宁具有剂量依赖性的热出汗抑制作用,而平行对照甲氧胺等无此作用;(2)育亨宾对可乐宁的抑汗效应具有竞争性拮抗作用;(3)可乐宁的最大抑汗范围仪3.66±0.31cm~2;(4)伍用烟酸使局部血管扩张对可乐宁的局部抑汗作用没有影响;(5)可乐宁对匹罗卡品的局部致汗作用没有影响。提示(1)可乐宁的局部抑汗作用具有药物特异性;(2)该作用系可乐宁激动给药局部的α_2肾上腺素受体而产生;(3)该作用并非可乐宁的中枢、脊髓及交感神经节等效应所致;(4)该作用并非可乐宁的局部缩血管效应所致;(5)该作用亦非可乐宁直接抑制汗腺或干扰汗腺胆碱能M受体与其激动剂的结合所致。认为存在人体汗腺胆碱能神经的抑制性突触前α_2肾上腺素受体,可乐宁通过激动这些受体,抑制递质乙酰胆碱的释放而抑制出汗的可能性。
Experimental observation of 13 subjects given subcutaneous injection of clonidine and other 0.1ml on local sweat rate, local activity sweat gland number, local optical pulse wave and local skin temperature and other indicators. Found that (1) a dose-dependent thermal sweat inhibition in the administration of topical clonidine, whereas parallel control methoxyamine and the like did not; (2) yohimbine had a competitive antagonistic effect on the anti-khan effect of clonidine ; (3) the maximum anti-Khan sweat range instrument 3.66 ± 0.31cm ~ 2; (4) the use of niacin to local vasodilation on the local anti-kalnic effect no effect; (5) Local sweat effect has no effect. Tip (1) the local anti-kleaning effect of clonidine has drug-specificity; (2) the effect of clonidine agonist administration of local α 2 adrenergic receptor generated; (3) this effect is not the center of the Ke Laning, spinal cord and Sympathetic ganglia and other symptomatic effects; (4) this effect is not caused by the clotting effect of clonidine; (5) this effect is also not the direct effect of clonidine on the sweat glands or interfere with the synaptic cholinergic M receptor and its agonist binding Due. It is thought that there is an inhibitory presynaptic [alpha] 2 adrenergic receptor of the cholinergic nerve of human sweat gland and that clonidine inhibits the possibility of sweating by activating these receptors and inhibiting the release of the transmitter acetylcholine.