带状疱疹是由于潜伏的水痘-带状疱疹病毒活化发生的全身感染性疾病,临床表现发烧、全身中毒、发疹和神经系统损害的各种综合症状。患者多伴有免疫缺陷,特别是长期使用皮质激素的病人或老年人。近年来,发现的抗病毒药物无环鸟苷(aciclovir),具有很高的抗单纯疱疹病毒和抗水痘-带状疱疹病毒的活性,为抑制病毒的DNA复制,无环鸟苷必须磷酸化,首先受病毒特异性的胸腺嘧啶核苷激酶的作用,而转变为单磷酸无环鸟苷,进一步在病毒感染的细胞 Shingles are systemic infections caused by latent varicella-zoster virus activation, clinical manifestations of fever, systemic poisoning, rash and various symptoms of nervous system damage. Patients often accompanied by immune deficiency, especially long-term use of corticosteroids in patients or the elderly. In recent years, the antiviral drug aciclovir has been found to have high activity against herpes simplex virus and varicella-zoster virus. Acyclovir must be phosphorylated to inhibit the DNA replication of the virus, First by the virus-specific thymidine kinase role, and into acyclohexin monophosphate, further in the virus-infected cells