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本文报道了黄体酮鼻腔给药系统的体外释药,以及鼻腔、口服和静注的药动学比较。鼻腔给药系统的制备将微孔膜做成一套管(5cm×2mm),插入一根长6cm的薄型聚乙烯管至4.5cm处,封住两端。插进家兔的鼻腔,注入0.35ml供试药物混悬液,密封,观察6小时。系统充满药液后,微孔膜膨胀,使给药系统与鼻腔粘膜充分接触,有利于药物吸收。用于制备药液的溶媒为等渗含20％聚乙二醇4000pH8的磷酸缓冲液,聚乙二醇4000用以增加黄体酮的溶解度。体外试验
This paper reports the release of progesterone nasal delivery system in vitro, as well as pharmacokinetic comparison of nasal, oral and intravenous injection. Preparation of nasal delivery system The microporous membrane was made into a tube (5 cm x 2 mm) and a 6 cm long thin polyethylene tube was inserted to 4.5 cm to seal both ends. Into the rabbit’s nasal cavity, into the test drug suspension 0.35ml, sealed and observed for 6 hours. After the system is filled with the liquid medicine, the microporous membrane expands, which makes the drug delivery system fully contact with the nasal mucosa, which is good for drug absorption. The vehicle used to prepare the drug solution was an isotonic phosphate buffer containing 20% polyethylene glycol 4000 pH 8, and polyethylene glycol 4000 was used to increase the solubility of progesterone. In vitro test