南京大学化学化工学院张艳课题组围绕光活性分子的反应和应用开展了多学科交叉的研究工作,最近在基于光活性分子的化学生物学研究取得了重要进展。该课题组近期在《美国化学会志》上报道了一例基于光活性分子修饰的新型短肽光敏性超分子水凝胶,在这项工作中,作者巧妙地使用一个可以在温和的光照条件下发生快速的分子内“光点击”反应的二芳基取代四氮唑分子作为“光扳机”。将此“光扳机”修饰在 Zhang Yan from Nanjing University School of Chemistry and Chemical Engineering has conducted a multidisciplinary research project focusing on the reaction and application of photoactive molecules. Recently, significant progress has been made in the field of chemical biology based on photoactive molecules. In the recent report of the American Chemical Society, the group recently reported a novel short peptide photosensitized supramolecular hydrogel based on photoactive molecule modification. In this work, the author cleverly used a device that can be used under mild lighting conditions The rapid intramolecular “click-click” reaction of diaryl-substituted tetrazolium molecules acts as the “light trigger.” This “light trigger ” in the modified