成人Still病(Adult-onset still’s disease,AOSD)是类风湿关节炎的一个特殊亚型,一般来说患者对非甾体类抗炎药、糖皮质激素的治疗相对敏感和有效,预后相对良好。但是有少数的患者用多种慢作用抗风湿药治疗无效,需要用大剂量的激素长期治疗,撤药困难,最终导致严重感染或呼吸窘迫等严重的结局[1]。本文报告用Etanercep(益赛普)成功治疗1例难治性AOSD患者。1临床资料 Adult-onset still disease (AOSD) is a special subtype of rheumatoid arthritis. Generally, patients are relatively sensitive and effective in the treatment of non-steroidal anti-inflammatory drugs and glucocorticoids. The prognosis is relatively good. However, a small number of patients with a variety of slow-acting anti-rheumatic drugs ineffective treatment, requiring long-term high-dose hormone therapy, withdrawal difficulties, and ultimately lead to serious infections or respiratory distress and other serious outcomes [1]. This article reports the successful treatment of 1 refractory AOSD patient with Etanercep (Isphaset). 1 clinical data