论文部分内容阅读
目的:研究乳腺浸润性导管癌PTEN的表达及与临床病理因素的关系。方法:选取在2002年-2012年间于我院接受治疗乳腺浸润性导管癌100位患者的石蜡标本,使用S-P法检测PTEN的表达结果,研究患者绝经状态,肿瘤位置及大小,组织学分级,年龄大小,腋窝淋巴结转移,临床分期与PTEN蛋白表达情况的关系。与非癌乳腺组织标本进行比较。结果:乳腺浸润性导管癌组织的PTEN蛋白表达率显著低于非癌性乳腺组织,比较差异有统计学意义(P<0.05);PTEN随着组织学分级增高而增高,与此相反表达率依次下降;腋窝淋巴结转移数目增加PTEN蛋白高表达率降低,比较差异有统计学意义(P<0.05);患者绝经状态,肿瘤位置及大小,组织学分级,年龄大小,临床分期与PTEN蛋白表达无关。结论:乳腺浸润性导管癌患者PTEN蛋白表达率与腋窝淋巴结转移紧密相关。
Objective: To investigate the expression of PTEN in breast invasive ductal carcinoma and its relationship with clinicopathological factors. Methods: The paraffin specimens from 100 patients with invasive ductal carcinoma of the breast in our hospital from 2002 to 2012 were selected. The expression of PTEN was detected by SP method. The postmenopausal status, tumor location and size, histological grade, age Size, Axillary Lymph Node Metastasis, Clinical Staging and PTEN Protein Expression. And non-cancerous breast tissue samples were compared. Results: The expression of PTEN in breast invasive ductal carcinoma tissues was significantly lower than that in non-cancerous breast tissues (P <0.05), while the expression of PTEN increased with the histological grade (P <0.05). The menopausal status, tumor location and size, histological grade, age, clinical stage had no correlation with the expression of PTEN protein in the patients with axillary lymph node metastasis. Conclusion: The expression of PTEN protein in breast invasive ductal carcinoma is closely related to axillary lymph node metastasis.